http://www.ewot-o2integralsports.com/research.html

Anti-Aging & Athletic Performance

Aging is characterized by a general decrease in O2 supply to tissues and a reduction in tissue pO2. A diminished vascularization in aging alters the diffusion of O2 at the capillary tissue level.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4543034/

Aging is associated with both hypoxia (38% reduction in oxygen levels, Po2 21.7 mmHg) and increases reactive oxygen species in visceral fat depots of aging male C57Bl/6 mice.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3275102/

In a clinical examination of 46 patients with EWOT, about 2/3 experienced an increase of resting values of arterial oxygen pressure.  This effect continues more than 3 months after the end of O2MT [EWOT], demonstrating prophylactic and therapeutic effects, including improvement of cardiorespiratory and cardiovascular efficiency, especially for the use of preventive-treatment and gerontology-therapy.

https://www.ncbi.nlm.nih.gov/pubmed/7222733

Double-blind study on 20 male healthy volunteers from the working population showed a 17% improvement of the energetic or oxygenation state of the subjects two-weeks after the completion of two 15-minute EWOT sessions.

https://www.ncbi.nlm.nih.gov/pubmed/6711017

59 patient’s mental capacity was measured by computer-based-methods before and after EWOT and compared to 14 controls.  The test group saw a 19-23% improvement in short term memory and times needed for the accomplishment of perception, interference and reaction tests became significantly shorter by 12-18%

https://www.ncbi.nlm.nih.gov/pubmed/2711706

The beneficial effects of EWOT can persist for weeks, months or even years.

https://www.ncbi.nlm.nih.gov/pubmed/6475110

Cancer, Inflammation & The Immune System

Over 70 years ago, Warburg showed that cells could always be made cancerous by subjecting them to periods of hypoxia.

https://www.ncbi.nlm.nih.gov/pubmed/17656037

In metastatic cells, the accelerated cell proliferation will further increase the level of hypoxia due to the increased cell accumulation, potentially forming a vicious cycle.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493170/

Higher oxygen status of a tumor correlates to higher survival rate:  22 patients with nonmetastatic, high-grade, soft tissue sarcomas underwent preoperative irradiation and hyperthermia and pretreatment measurement of tumor oxygenation.  The 18-month actuarial disease-free survival was 70% for patients with tumor median oxygen pressure (pO2) values of >10 mm Hg but only 35% for those with median pO2 values of < 10 mm Hg (P = 0.01).  Median pO2 was 7.5 mm Hg for metastasizing tumors versus 20 mm Hg for non-metastasizing tumors (P = 0.03).

http://cancerres.aacrjournals.org/content/56/5/941

With the 15-minute EWOT sessions and desiccated thymus pills, precancerous skin lesions were unprimed within 10 months.

https://www.ncbi.nlm.nih.gov/pubmed/4049925

Hypoxia can induce inflammation.  In persons with mountain sickness, for example, levels of circulating proinflammatory cytokines increase, and vascular leakage causes pulmonary or cerebral edema.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930928/

Hypoxia and inflammation are two sides of the same coin

http://www.pnas.org/content/110/46/18351